眼部环核苷酸门控通道受尼古丁调节。
Eye CNG channel is modulated by nicotine.
作者信息
McGeoch J E, McGeoch M W, Guidotti G
机构信息
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
出版信息
Biochem Biophys Res Commun. 1995 Sep 25;214(3):879-87. doi: 10.1006/bbrc.1995.2369.
PMID:7575559
Abstract
The cyclic-nucleotide gated channel (CNG channel) of the rod outer segment of the retina (ROS) has its closed conformation stabilized by nicotine. Calcium and cGMP influence the Ki of the channel current to nicotine. Calcium lowers the Ki and cGMP increases it, giving a range of Ki between 10(-11) and 10(-8) M.
摘要
视网膜视杆外段（ROS）的环核苷酸门控通道（CNG通道）的关闭构象可被尼古丁稳定。钙和环磷酸鸟苷（cGMP）会影响通道电流对尼古丁的抑制常数（Ki）。钙会降低Ki，而cGMP会升高Ki，使得Ki的范围在10^(-11)至10^(-8) M之间。
Zotero 插件