van der Heide A, Remme C A, Hofman D M, Jacobs J W, Bijlsma J W
Arthritis Research Foundation of Utrecht (Stichting Reumaonderzoek Utrecht [SRU]), The Netherlands.
Arthritis Rheum. 1995 Oct;38(10):1466-74. doi: 10.1002/art.1780381013.
To investigate the extent to which early radiologic damage is predicted by joint inflammation in patients with newly diagnosed rheumatoid arthritis (RA).
Regression analysis was performed on 1-year progression of total radiologic damage for baseline characteristics and cumulative disease activity measures, and the effects of continued joint inflammation on the progression of damage in separate joint groups were investigated.
Odds ratios for progression of total damage were 12 for the presence of rheumatoid factor, 5 for the presence of damage at baseline, and 2 for cumulative joint inflammation. A positive association between continued joint inflammation and progression of damage was found to be statistically significant for most joint groups.
Progression of radiologic damage in patients with newly diagnosed RA is independently associated with the presence of rheumatoid factor and damage at baseline and with cumulative joint inflammation.
探讨新诊断类风湿关节炎（RA）患者中关节炎症对早期放射学损伤的预测程度。
对基线特征和累积疾病活动度指标的1年总放射学损伤进展进行回归分析，并研究持续关节炎症对不同关节组损伤进展的影响。
类风湿因子阳性时总损伤进展的优势比为12，基线存在损伤时为5，累积关节炎症时为2。发现持续关节炎症与损伤进展之间的正相关在大多数关节组中具有统计学意义。
新诊断RA患者的放射学损伤进展与类风湿因子的存在、基线损伤以及累积关节炎症独立相关。
