小鼠CD38：一种免疫调节性外切酶。
Murine CD38: an immunoregulatory ectoenzyme.
作者信息
Lund F, Solvason N, Grimaldi J C, Parkhouse R M, Howard M
机构信息
DNAX Research Institute, Palo Alto, CA 94304, USA.
出版信息
Immunol Today. 1995 Oct;16(10):469-73. doi: 10.1016/0167-5699(95)80029-8.
PMID:7576049
Abstract
CD38 is an ectoenzyme that utilizes NAD+ and is expressed by many cells of hematopoietic origin. Antibodies to CD38 potentiate many biological activities on lymphocytes, including induction of murine B-cell proliferation. In this article, Frances Lund and colleagues summarize information concerning the expression, enzymatic activity and signal transduction pathway utilized by murine CD38.
摘要
CD38是一种利用NAD+的胞外酶，由许多造血起源的细胞表达。抗CD38抗体可增强淋巴细胞的多种生物学活性，包括诱导小鼠B细胞增殖。在本文中，弗朗西斯·伦德及其同事总结了有关小鼠CD38的表达、酶活性和信号转导途径的信息。
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