Morgan M A, LeDoux J E
Department of Psychology, New York University, USA.
Behav Neurosci. 1995 Aug;109(4):681-8. doi: 10.1037//0735-7044.109.4.681.
The emotional reactivity of rats with lesions of the dorsal portion of medial prefrontal cortex (mPFC) was examined using a classical fear conditioning paradigm. Conditioned fear behavior (freezing responses) was measured during both the acquisition and extinction phases of the task. Lesions enhanced fear reactivity to both the conditioned stimulus (CS) and contextual stimuli during both phases, suggesting that dorsal mPFC lesions produce a general increase in fear reactivity in response to fear conditioning. M. A. Morgan, L. M. Romanski, and J. E. LeDoux (1993) found that lesions just ventral to the present lesions had no effect during acquisition of the same task and prolonged the fear response to the CS (but not the context) during extinction. Thus, both dorsal and ventral regions of mPFC are involved in the fear system, but each modulates different aspects of fear responsivity.
使用经典恐惧条件范式检测了内侧前额叶皮质（mPFC）背侧损伤大鼠的情绪反应性。在任务的习得和消退阶段均测量了条件性恐惧行为（僵住反应）。损伤在两个阶段均增强了对条件刺激（CS）和情境刺激的恐惧反应性，这表明背侧mPFC损伤会导致在恐惧条件作用下恐惧反应性普遍增加。M. A. 摩根、L. M. 罗曼斯基和J. E. 勒杜（1993年）发现，在相同任务的习得过程中，恰好在当前损伤部位腹侧的损伤没有影响，并且在消退过程中延长了对CS（而非情境）的恐惧反应。因此，mPFC的背侧和腹侧区域均参与恐惧系统，但各自调节恐惧反应性的不同方面。
