Ahmed S H, Cador M, Le Moal M, Stinus L
INSERM U259, Université de Bordeaux II, France.
Behav Neurosci. 1995 Aug;109(4):723-33. doi: 10.1037//0735-7044.109.4.723.
A within-subject design was used to investigate the behavioral and neural basis of the conditioned activity induced by amphetamine in male Wistar rats. In this design, conditioned activity was inferred when the activity of a given rat following a vehicle injection was greater in its amphetamine-paired environment (CS+) than in its vehicle-paired environment (CS-). Conditioned activity (a) did not change in magnitude with the number of conditioning sessions, (b) did not differ from the level of activity recorded during the first exposure to the CS- (novelty), (c) had an extinction rate that was similar to the rate of habituation to the CS-, and (d) was not impaired by a bilateral excitotoxic lesion of the basolateral amygdala. Results are discussed in light of the incentive conditioning and habituation theories of conditioned activity.
采用被试内设计来研究苯丙胺在雄性Wistar大鼠中诱导的条件性活动的行为和神经基础。在该设计中，当给予大鼠注射赋形剂后，其在与苯丙胺配对的环境（CS+）中的活动比在与赋形剂配对的环境（CS-）中更活跃时，可推断出条件性活动。条件性活动（a）的幅度不会随着条件化训练次数的增加而改变，（b）与首次暴露于CS-（新奇环境）期间记录的活动水平没有差异，（c）其消退率与对CS-的习惯化率相似，并且（d）不受基底外侧杏仁核双侧兴奋性毒性损伤的影响。根据条件性活动的动机性条件作用和习惯化理论对结果进行了讨论。
