Polico C, Nascimben O, Maccari F, Fazzin G
Quad Sclavo Diagn. 1978 Dec;14(4):486-93.
Serial estimations of the hydroxyproline (OHP) excretion during chemotherapy were performed in 24 women bearing advanced breast carcinoma with skeletal metastases. There was a significant correlation between sensitivity of the metastases to treatment and OHP content of urine. Many factors, including age of patients, type, number and extent of metastases, don't influence OHP excretion. The estimation of the urinary OHP levels, with the changes after antiblastic treatment, can be useful in prognostic evaluation of the metastatic breast cancer.
对24例患有晚期乳腺癌伴骨转移的女性患者在化疗期间进行了羟脯氨酸（OHP）排泄的系列评估。转移灶对治疗的敏感性与尿液中的OHP含量之间存在显著相关性。许多因素，包括患者年龄、转移灶的类型、数量和范围，均不影响OHP的排泄。通过评估尿液中OHP水平以及抗胚细胞治疗后的变化，有助于对转移性乳腺癌进行预后评估。
