Schafe G E, Sollars S I, Bernstein I L
Department of Psychology, University of Washington, Seattle 98195, USA.
Behav Neurosci. 1995 Aug;109(4):799-802.
Temporal parameters of taste aversion learning are known to differ markedly from other learning paradigms in that acquisition occurs despite lengthy delays between exposure to conditioned (CS) and unconditioned stimulus (US). Far less consideration has been paid to very brief CS-US intervals and the possibility that this learning may also be distinguished by an ineffectiveness of close temporal contiguity between CS and US. The effectiveness of a very brief CS-US interval (10 s) was compared with that of 2 lengthier intervals (15 and 30 min). Temporal control of CS delivery (0.15% saccharin solution) into the oral cavity and US delivery (7.5 mg/kg apomorphine hydrochloride) into circulation involved infusion pumps and indwelling catheters. Using a 1-trial learning paradigm, CS-US delays of 15 and 30 min led to significant aversions whereas the 10-s CS-US interval did not, suggesting that close temporal contiguity between CS and US is neither necessary nor sufficient for conditioned taste aversion acquisition.
已知味觉厌恶学习的时间参数与其他学习范式有显著差异，因为尽管条件刺激（CS）和非条件刺激（US）之间存在长时间延迟，但习得仍会发生。对于非常短暂的CS-US间隔以及这种学习可能也因CS和US之间紧密的时间接近无效而有所区别的可能性，人们的关注要少得多。将非常短暂的CS-US间隔（10秒）的有效性与2个更长间隔（15和30分钟）的有效性进行了比较。将CS（0.15%糖精溶液）输送到口腔以及将US（7.5毫克/千克盐酸阿扑吗啡）输送到循环系统的时间控制涉及输液泵和留置导管。使用单次试验学习范式，15分钟和30分钟的CS-US延迟导致了显著的厌恶，而10秒的CS-US间隔则没有，这表明CS和US之间紧密的时间接近对于条件性味觉厌恶的习得既非必要也不充分。
