Serraino D, Franceschi S, Dal Maso L, La Vecchia C
Department of Epidemiology, Aviano Cancer Centre, Italy.
AIDS. 1995 Aug;9(8):971-3. doi: 10.1097/00002030-199508000-00022.
To assess the association between the presence of Kaposi's sarcoma (KS) as an AIDS-defining illness and HIV transmission categories among European women with AIDS.
Comparison of the prevalence of KS as an AIDS-defining illness in different HIV transmission categories.
Odds ratios (OR) and 95% confidence intervals (CI) for KS were computed by means of unconditional multiple logistic regression equations.
KS was reported in 344 (2.2%) out of 15,809 women diagnosed with AIDS. Women who reported HIV infection via heterosexual intercourse had a > twofold increase of KS risk than intravenous drug users (OR, 2.4; 95% CI, 1.9-3.0). Particularly elevated OR were observed among women originating from African or Caribbean countries (OR, 4.9; 95% CI, 3.7--6.5), and in partners of bisexual men (OR, 4.8; 95% CI, 2.8--8.2). Such risk patterns for KS were consistent in different countries, age groups and year of AIDS diagnosis.
These results are in agreement with similar analyses from the United States, and support the existence of some putative KS agent(s) which can be acquired via sexual intercourse with bisexual men, or earlier in life in countries where non-AIDS-associated KS is frequent.
评估卡波西肉瘤（KS）作为艾滋病界定疾病的存在与欧洲艾滋病女性患者中HIV传播类别之间的关联。
比较不同HIV传播类别中KS作为艾滋病界定疾病的患病率。
通过无条件多因素逻辑回归方程计算KS的比值比（OR）和95%置信区间（CI）。
在15809名被诊断为艾滋病的女性中，有344名（2.2%）报告患有KS。报告通过异性性行为感染HIV的女性患KS的风险比静脉吸毒者高出两倍多（OR，2.4；95%CI，1.9 - 3.0）。在来自非洲或加勒比国家的女性（OR，4.9；95%CI，3.7 - 6.5）以及双性恋男性的伴侣中（OR，4.8；95%CI，2.8 - 8.2）观察到特别高的OR。KS的这种风险模式在不同国家、年龄组和艾滋病诊断年份中是一致的。
这些结果与美国的类似分析一致，并支持存在一些假定的KS病原体，这些病原体可通过与双性恋男性发生性行为或在非艾滋病相关KS常见的国家早年获得。
