Serraino D, Franceschi S
Epidemiology Unit, Aviano Cancer Center, Pordenone, Italy.
AIDS. 1996 Jun;10(6):643-7. doi: 10.1097/00002030-199606000-00010.
To assess the proportion of, and the characteristics associated with, Kaposi's sarcoma (KS) and non-Hodgkin's lymphomas (NHL) in children (0-12 years) and adolescents (13-19 years) at AIDS diagnosis, in Europe and in the United States (US).
Comparison of the proportions of KS and NHL at AIDS diagnosis, according to various characteristics, by means of the European Non-Aggregate AIDS Data Set (4400 children and 764 adolescents) and the US AIDS Public Information Data Set (4710 children and 1064 adolescents) updated to June 1993.
Comparison of data was made using odds ratios (OR) and corresponding 95% confidence intervals.
Between 0 and 19 years, the proportion of KS at AIDS diagnosis (0.5% in Europe and 0.9% in the US) increased with age, particularly in Europe, and was higher in males than in females. It decreased with time in the US but not in Europe. In the US, black children showed a nearly threefold excess of KS as compared with white children. Adolescents who reported homosexual intercourse with other males had significantly elevated risks of KS, both in Europe (OR, 6.3) and in the US (OR, 21.1). NHL was diagnosed in 0.9% of children in Europe and in 1.5% in the US. The proportion of NHL significantly increased with age (3.1% among adolescents in Europe and 3.0% in the US), and was higher in males than in females. In the US, NHL tended to decline in proportion with all AIDS cases over time and showed a nearly twofold higher frequency in white children. No association emerged between NHL and HIV transmission category.
In agreement with incidence rates in the general paediatric population, but at variance with AIDS in adults, NHL turned out to be more common than KS in children and adolescents with AIDS. A strong excess of KS was already present in adolescents who reported homosexual intercourse.
评估欧洲和美国0至12岁儿童及13至19岁青少年艾滋病诊断时卡波西肉瘤（KS）和非霍奇金淋巴瘤（NHL）的比例及其相关特征。
通过欧洲非汇总艾滋病数据集（4400名儿童和764名青少年）以及更新至1993年6月的美国艾滋病公共信息数据集（4710名儿童和1064名青少年），根据各种特征比较艾滋病诊断时KS和NHL的比例。
使用比值比（OR）和相应的95%置信区间进行数据比较。
在0至19岁之间，艾滋病诊断时KS的比例（欧洲为0.5%，美国为0.9%）随年龄增长而增加，在欧洲尤为明显，男性高于女性。在美国，其比例随时间下降，但在欧洲并非如此。在美国，黑人儿童患KS的几率比白人儿童高出近三倍。报告与其他男性有同性恋行为的青少年患KS的风险显著升高，在欧洲（OR为6.3）和美国（OR为21.1）均如此。欧洲0.9%的儿童和美国1.5%的儿童被诊断为NHL。NHL的比例随年龄显著增加（欧洲青少年中为3.1%，美国为3.0%），男性高于女性。在美国，NHL在所有艾滋病病例中的比例随时间呈下降趋势，在白人儿童中的发病率几乎高出一倍。NHL与HIV传播类别之间未发现关联。
与一般儿科人群的发病率一致，但与成人艾滋病情况不同，在患有艾滋病的儿童和青少年中，NHL比KS更常见。报告有同性恋行为的青少年中KS的发病率已经很高。
