González M, Retaco P, Pizzorno M T, Volonté M G
Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina.
Boll Chim Farm. 1995 Sep;134(8):448-53.
The effect of the manufacturing technology on the dissolution of ampicillin tablets have been analyzed. Several kinetic parameters were then calculated. The dissolution rate of ampicillin increases in tablets prepared by direct compression or dry granulation, with microcrystalline cellulose and colloidal silicon dioxide. Studies of in vitro bioequivalence of the pharmaceutical products available in the Argentine market were performed. We concluded that not all commercial products are equivalent.
分析了制造工艺对氨苄西林片溶出度的影响。然后计算了几个动力学参数。在由微晶纤维素和胶体二氧化硅通过直接压片或干法制粒制备的片剂中，氨苄西林的溶出速率增加。对阿根廷市场上可得的药品进行了体外生物等效性研究。我们得出结论，并非所有商业产品都是等效的。
