Blomgren H, Lax I, Näslund I, Svanström R
Department of Oncology, Karolinska Hospital, Stockholm, Sweden.
Acta Oncol. 1995;34(6):861-70. doi: 10.3109/02841869509127197.
A stereotactic body frame with a fixation device has been developed for stereotactic radiation therapy of extracranial targets, a precision localization and positioning system in analogy with the stereotactic head frames used for intracranial targets. Results of the first 42 treated tumors in 31 patients are presented. Most of the patients had solitary tumors in liver, lung or retroperitoneal space. Clinical target volumes ranged from 2 to 622 cm3 (mean 78 cm3) and minimum doses to the planning target volumes (PTV) of 7.7-30 Gy/fraction (mean 14.2 Gy) were given on 1-4 occasions to a total minimum dose to the PTVs of 7.7-45 Gy (mean 30.2 Gy) to the periphery of the PTV and total mean doses to the PTVs of 8-66 Gy (mean 41 Gy). The central part of the tumor was usually given about 50% higher dose compared to that of the periphery of the PTV by a planned inhomogeneous dose distribution. Some of the patients received stereotactic radiation therapy concomitantly to more than one target, in others new metastases were also treated which appeared during the follow-up period. We observed a local rate of no progressive disease of 80% during a follow-up period of 1.5-38 months. Fifty percent of the tumors decreased in size or disappeared.
一种带有固定装置的立体定向体架已被开发用于颅外靶点的立体定向放射治疗，这是一种类似于用于颅内靶点的立体定向头架的精确定位和定位系统。本文介绍了31例患者中前42例接受治疗的肿瘤的结果。大多数患者在肝脏、肺部或腹膜后间隙有孤立性肿瘤。临床靶体积范围为2至622 cm³（平均78 cm³），计划靶体积（PTV）的最小剂量为7.7 - 30 Gy/分次（平均14.2 Gy），分1至4次给予，PTV周边的总最小剂量为7.7 - 45 Gy（平均30.2 Gy），PTV的总平均剂量为8 - 66 Gy（平均41 Gy）。通过计划的非均匀剂量分布，肿瘤中心部分的剂量通常比PTV周边部分高约50%。一些患者同时接受了针对多个靶点的立体定向放射治疗，在其他患者中，随访期间出现的新转移灶也得到了治疗。在1.5至38个月的随访期内，我们观察到局部无进展疾病率为80%。50%的肿瘤体积缩小或消失。
