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JAMA Oncol. 2023 Sep 1;9(9):1245-1254. doi: 10.1001/jamaoncol.2023.2535.
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肝脏肿瘤的立体定向体部放疗：介入放射科医生需要了解的内容。

SBRT for Liver Tumors: What the Interventional Radiologist Needs to Know.

作者信息

Gutman Michael J, Serra Lucas M, Koshy Matthew, Katipally Rohan R

机构信息

Department of Radiation and Cellular Oncology, The University of Chicago Medicine, Chicago, Illinois.

出版信息

Semin Intervent Radiol. 2024 Mar 14;41(1):1-10. doi: 10.1055/s-0043-1778657. eCollection 2024 Feb.

DOI:10.1055/s-0043-1778657
PMID:38495259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10940045/
Abstract

This review summarizes the clinical evidence supporting the utilization of stereotactic body radiotherapy (SBRT) for liver tumors, including hepatocellular carcinoma, liver metastases, and cholangiocarcinoma. Emerging prospective evidence has demonstrated the benefit and low rates of toxicity across a broad range of clinical contexts. We provide an introduction for the interventional radiologist, with a discussion of underlying themes such as tumor dose-response, mitigation of liver toxicity, and the technical considerations relevant to performing liver SBRT. Ultimately, we recommend that SBRT should be routinely included in the armamentarium of locoregional therapies for liver malignancies, alongside those liver-directed therapies offered by interventional radiology.

摘要

本综述总结了支持立体定向体部放疗（SBRT）用于肝脏肿瘤（包括肝细胞癌、肝转移瘤和胆管癌）的临床证据。新出现的前瞻性证据表明，在广泛的临床情况下，SBRT具有益处且毒性发生率较低。我们为介入放射科医生提供了介绍，讨论了诸如肿瘤剂量反应、减轻肝脏毒性以及与进行肝脏SBRT相关的技术考虑等潜在主题。最终，我们建议SBRT应常规纳入肝脏恶性肿瘤局部区域治疗手段中，与介入放射学提供的那些肝脏定向治疗手段一起。