Malouf D J, Oates R K
Sydney University Department of Paediatrics and Child Health, Children's Hospital, Camperdown, New South Wales, Australia.
J Paediatr Child Health. 1995 Aug;31(4):332-5. doi: 10.1111/j.1440-1754.1995.tb00822.x.
To review the experience of the Camperdown Children's Hospital with neonatal herpes simplex viral (HSV) infections between 1960 and 1992.
A retrospective record review of all cases of HSV infection.
Fifteen proven HSV infections were found. Only three cases had a definite history of HSV infection during pregnancy. Six were delivered at 36 weeks gestation or earlier. Seven weighed 2500 g or less. Forty-three per cent developed physical signs within 7 days of birth. Three cases were confined to skin, eyes and mouth, five were generalized, six had encephalitis with or without skin lesions, and one had pneumonitis. The mortality rate comprising the five with generalized infection was 47%, one with encephalitis and the one with pneumonitis. Four of the eight survivors have persisting neurological impairment. Those with disseminated infection and encephalitis did poorly regardless of antiviral treatment.
A high index of suspicion of HSV infection is important so that antiviral treatment can be commenced early, particularly for those infections localized to skin, eye and mouth where there may be a good prognosis.
回顾1960年至1992年间坎珀当儿童医院新生儿单纯疱疹病毒（HSV）感染的经验。
对所有HSV感染病例进行回顾性记录审查。
发现15例确诊的HSV感染。只有3例在孕期有明确的HSV感染史。6例在妊娠36周或更早分娩。7例体重在2500克或以下。43%的患儿在出生后7天内出现体征。3例局限于皮肤、眼睛和口腔，5例全身性感染，6例有脑炎伴或不伴皮肤病变，1例有肺炎。包括5例全身性感染、1例脑炎和1例肺炎患儿在内的死亡率为47%。8名幸存者中有4名存在持续性神经功能障碍。无论是否进行抗病毒治疗，播散性感染和脑炎患儿的预后都很差。
高度怀疑HSV感染很重要，以便尽早开始抗病毒治疗，特别是对于那些局限于皮肤、眼睛和口腔的感染，其预后可能较好。
