Baldursson B, Sigurgeirsson B, Lindelöf B
Department of Dermatology, Gävle Hospital, Sweden.
Br J Dermatol. 1995 Oct;133(4):571-4. doi: 10.1111/j.1365-2133.1995.tb02707.x.
In order to obtain a precise estimate of the relative risk of squamous cell carcinoma (SCC) in venous leg ulcers, we matched 10,913 patients with the diagnosis venous leg ulcer from the Swedish Inpatient Registry with registrations of SCC of the lower limb recorded by the Swedish Cancer Registry, and found 33 cases of non-melanoma skin cancer. After scrutinizing the pathology and case records, 17 cases of SCC were considered as being certainly secondary to venous leg ulcers, whereas in six cases of remitting/relapsing ulcers the connection was probable. The relative risk calculated on 17 cases was 5.80 (95% confidence interval = 3.08-9.29). The median duration of the ulcer before the diagnosis of cancer was 25 years. The mean follow-up time of the cohort was 8.5 years. We conclude that SCC is a complication of chronic venous leg ulcers, although the absolute risk is very small.
为了精确估计下肢静脉溃疡患者发生鳞状细胞癌（SCC）的相对风险，我们将瑞典住院患者登记处确诊为下肢静脉溃疡的10913名患者与瑞典癌症登记处记录的下肢SCC登记信息进行匹配，发现了33例非黑色素瘤皮肤癌病例。在仔细检查病理和病例记录后，17例SCC被认为肯定继发于下肢静脉溃疡，而在6例缓解/复发溃疡病例中，两者之间可能存在关联。根据17例病例计算出的相对风险为5.80（95%置信区间=3.08-9.29）。癌症诊断前溃疡的中位持续时间为25年。该队列的平均随访时间为8.5年。我们得出结论，SCC是慢性下肢静脉溃疡的一种并发症，尽管绝对风险非常小。
