血浆置换治疗重症局限性硬皮病——三例报告

Treatment of severe localized scleroderma by plasmapheresis--report of three cases.

作者信息

Wach F, Ullrich H, Schmitz G, Landthaler M, Hein R

机构信息

Department of Dermatology, University of Regensburg, Germany.

出版信息

Br J Dermatol. 1995 Oct;133(4):605-9. doi: 10.1111/j.1365-2133.1995.tb02713.x.

DOI:10.1111/j.1365-2133.1995.tb02713.x

PMID:7577592

Abstract

We report three patients with severe, localized scleroderma, and with elevated titres of antinuclear antibodies, who were treated by plasmapheresis in combination with systemic steroid therapy. The therapeutic effectiveness of plasmapheresis was assessed on the basis of improvement in cutaneous and joint lesions. In all cases, significant improvement occurred after 2 months of therapy. Thus, in addition to treating systemic sclerosis, plasmapheresis can also be recommended for treatment of severe cases of localized scleroderma with elevated titres of antinuclear antibodies and antibodies to ss-DNA.

摘要

我们报告了3例患有严重局限性硬皮病且抗核抗体滴度升高的患者，他们接受了血浆置换联合全身类固醇治疗。根据皮肤和关节病变的改善情况评估血浆置换的治疗效果。在所有病例中，治疗2个月后均出现显著改善。因此，除了治疗系统性硬化症外，血浆置换也可推荐用于治疗抗核抗体和抗单链DNA抗体滴度升高的严重局限性硬皮病病例。