Ramratnam B, Gollerkeri A, Schiffman F J, Rintels P, Flanigan T P
Department of Medicine, Miriam Hospital, Brown University School of Medicine, Providence, Rhode Island, USA.
Br J Haematol. 1995 Sep;91(1):90-2. doi: 10.1111/j.1365-2141.1995.tb05250.x.
An HIV+ 26-year-old white man with a CD4 count of 0.06 x 10(9)/l was found to have red blood cell aplasia secondary to B19 parvovirus infection. Regular infusions of intravenous immunoglobulin (IVIG) were begun and resulted in marked reticulocytosis and correction of anaemia. The patient has been followed for over 4 years and has become anaemic and reticulocytopenic whenever IVIG was interrupted. Serial dot blot analysis of the patient's sera for B19 parvovirus DNA showed absence of DNA immediately following IVIG treatments but reappearance within 3-6 weeks. Regular IVIG was effective in controlling but not eradicating B19 parvovirus infection in this HIV+ patient.
一名26岁的HIV阳性白人男性，CD4细胞计数为0.06×10⁹/L，被发现患有继发于B19细小病毒感染的红细胞再生障碍。开始定期静脉输注静脉注射免疫球蛋白（IVIG），结果导致明显的网织红细胞增多和贫血纠正。该患者已被随访4年多，每当IVIG中断时就会出现贫血和网织红细胞减少。对患者血清进行B19细小病毒DNA的系列斑点印迹分析显示，IVIG治疗后立即检测不到DNA，但在3 - 6周内重新出现。定期IVIG在控制这名HIV阳性患者的B19细小病毒感染方面有效，但不能根除。
