Fedele L, Bianchi S, Marchini M, Di Nola G
Department of Obstetrics and Gynecology, University of Milan, Italy.
Br J Obstet Gynaecol. 1995 Oct;102 Suppl 12:8-11. doi: 10.1111/j.1471-0528.1995.tb09159.x.
The medium- and long-term effects of gestrinone and danazol on the endometrium were examined in 36 patients with endometriosis. Endometrial biopsies were taken from each patient before treatment and after 3 and 6 months of treatment with 600 mg danazol daily (n = 17) or with 2.5 mg gestrinone twice weekly (n = 19). Endometrial samples were analysed by light, scanning and transmission electron microscopy. At 3 months' treatment the endometria of patients treated with danazol appeared more atrophic than those of the women treated with gestrinone; some cell organelle involution was evident in all patients. After 6 months of treatment a marked atrophy was observed in patients of both treatment groups. A complete involution of cytoplasmic organelles with cytoplasmic collapse and a shift of nucleoplasmic ratio in favour of the nucleus occurred in patients treated with danazol; the cytoplasmic organelle involution was less marked in patients treated with gestrinone. Compared with gestrinone, danazol induces more rapid endometrial atrophy, with greater impairment of the cytoplasm and cell secretory activity.
对36例子宫内膜异位症患者研究了孕三烯酮和达那唑对子宫内膜的中长期影响。在治疗前以及每日服用600mg达那唑（n = 17）或每周两次服用2.5mg孕三烯酮（n = 19）治疗3个月和6个月后，对每位患者进行子宫内膜活检。通过光学显微镜、扫描电子显微镜和透射电子显微镜对子宫内膜样本进行分析。治疗3个月时，接受达那唑治疗患者的子宫内膜比接受孕三烯酮治疗的女性的子宫内膜萎缩更明显；所有患者均可见一些细胞器退化。治疗6个月后，两个治疗组的患者均出现明显萎缩。接受达那唑治疗的患者出现细胞质细胞器完全退化、细胞质塌陷以及核质比向有利于细胞核的方向转变；接受孕三烯酮治疗的患者细胞质细胞器退化不那么明显。与孕三烯酮相比，达那唑可诱导子宫内膜更快萎缩，对细胞质和细胞分泌活性的损害更大。
