Forbes K L, Thomas F J
University of Queensland, Department of Obstetrics and Gynaecology, Royal Brisbane Hospital, Herston, Australia.
Reprod Fertil Dev. 1993;5(1):103-9. doi: 10.1071/rd9930103.
An open comparative study of gestrinone and danazol in the treatment of endometriosis demonstrated a similar decrease in the extent of active endometriotic deposits, assessed visually following therapy. Biochemical endocrinological changes during therapy with gestrinone showed that basal concentrations of gonadotrophin remained unchanged, oestradiol concentrations varied and the free fraction of testosterone increased. A similar range of side effects was reported in both treatment groups, consisting predominantly of 'androgenic' effects in 10 of 15 women treated with gestrinone and 5 of 12 treated with danazol. The results suggest that gestrinone is an effective alternative agent for the treatment of endometriosis.
一项关于炔诺酮和达那唑治疗子宫内膜异位症的开放性对照研究表明，治疗后通过视觉评估，活性子宫内膜异位病灶范围的减少程度相似。炔诺酮治疗期间的生化内分泌变化显示，促性腺激素的基础浓度保持不变，雌二醇浓度有所变化，睾酮的游离部分增加。两个治疗组报告的副作用范围相似，主要由“雄激素样”作用组成，在接受炔诺酮治疗的15名女性中有10名出现，在接受达那唑治疗的12名女性中有5名出现。结果表明，炔诺酮是治疗子宫内膜异位症的一种有效替代药物。
