Wittmann D H, Schein M, Seoane D, Aprahamian C, Komorowski R A, Georgakas K, Quebbeman E J, Wallace J R, Condon R E
Department of Surgery, Medical College of Wisconsin, Milwaukee 53226, USA.
Clin Infect Dis. 1995 Jul;21(1):162-70. doi: 10.1093/clinids/21.1.162.
Pyoderma fistulans sinifica (PFS, also referred to as fox den disease because its multiple fistulae and sinuses resemble the structure of a fox den) is a distinct chronic infectious disease in which epithelialized tracts form within the subdermal fatty tissue. PFS, which has not been previously described in the English-language literature, must be differentiated from hidradenitis suppurativa, pilonidal sinus, and perianal fistula. The fistulous tracts of PFS are always lined by stratified squamous-cell epithelium but, unlike those of hidradenitis, reach deep into the subcutaneous fat, run epifascially for long distances, and have no relation to skin appendices. We report on 10 men (mean age +/- SD, 36 +/- 5 years) with PFS (mean duration +/- SD, 11 +/- 7 years). Bacterial cultures of affected tissue from these patients yielded a total of 14 facultative and 31 obligate anaerobic species. Treatment consisted of wide en-bloc excision down to the fascia, including all fistulae. Antibiotic therapy temporarily reduced purulent discharge but did not eradicate the infection. Two patients who underwent fistulotomy without wide en-bloc excision developed recurrences.
中国化瘘管性脓皮病（PFS，也称为狐穴病，因为其多个瘘管和窦道类似于狐穴的结构）是一种独特的慢性传染病，在皮下脂肪组织内形成上皮化管道。PFS此前未在英文文献中被描述过，必须与化脓性汗腺炎、藏毛窦和肛周瘘管相鉴别。PFS的瘘管总是内衬复层鳞状上皮，但与化脓性汗腺炎的瘘管不同，它深入皮下脂肪，沿筋膜浅层延伸很长距离，且与皮肤附属器无关。我们报告了10例患有PFS的男性患者（平均年龄±标准差，36±5岁）（平均病程±标准差，11±7年）。对这些患者受影响组织进行的细菌培养共产生了14种兼性厌氧菌和31种专性厌氧菌。治疗包括广泛整块切除至筋膜，包括所有瘘管。抗生素治疗可暂时减少脓性分泌物，但无法根除感染。两名未进行广泛整块切除而仅接受瘘管切开术的患者复发。
