Osol G
Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington 05405, USA.
J Vasc Res. 1995 Sep-Oct;32(5):275-92. doi: 10.1159/000159102.
Mechanotransduction by vascular smooth muscle (VSM) is defined as a cellular response (contraction, secretion, growth, division) to transmural pressure or stretch. This review includes an overview of the physical forces VSM cells experience in vivo, consideration of experimental techniques used to study VSM mechanotransduction, and a discussion of the scientific literature pertinent to the individual cellular components that have been implicated in the transduction of physical forces. These include: the extracellular matrix, integrins, ion channels, the sarcoplasmic reticulum, second messenger systems, contractile proteins, and the cytoskeleton.
血管平滑肌（VSM）的机械转导被定义为细胞对跨壁压力或拉伸的反应（收缩、分泌、生长、分裂）。本综述包括对VSM细胞在体内所经历的物理力的概述，对用于研究VSM机械转导的实验技术的考量，以及对与参与物理力转导的各个细胞成分相关的科学文献的讨论。这些成分包括：细胞外基质、整合素、离子通道、肌浆网、第二信使系统、收缩蛋白和细胞骨架。
