D'Angelo G, Meininger G A
Department of Medical Physiology, College of Medicine, Texas A&M University Health Science Center, College Station 77843-1114.
Hypertension. 1994 Jun;23(6 Pt 2):1096-105. doi: 10.1161/01.hyp.23.6.1096.
Vascular smooth muscle has the ability to exist in a state of maintained partial constriction. This state of partial activation is initiated and/or maintained by the mechanical effects of distending pressure acting on the vascular wall. The intrinsic ability of vascular smooth muscle to respond to these mechanical forces is referred to as the myogenic mechanism. Within the past decade the signaling mechanisms responsible for mechanotransduction of myogenic phenomena have been the focus of extensive research. Two areas of active investigation include (1) the modulation of membrane ionic conductances by pressure/stretch and (2) the pressure/stretch-induced generation of second messengers known to be involved in vascular smooth muscle contraction. This review summarizes recent work aimed at understanding the mechanotransduction process in vascular smooth muscle.
血管平滑肌能够处于持续部分收缩的状态。这种部分激活状态是由作用于血管壁的扩张压力的机械效应引发和/或维持的。血管平滑肌对这些机械力作出反应的内在能力被称为肌源性机制。在过去十年中，负责肌源性现象机械转导的信号机制一直是广泛研究的焦点。两个活跃的研究领域包括：（1）压力/牵张对膜离子电导的调节；（2）压力/牵张诱导产生已知参与血管平滑肌收缩的第二信使。这篇综述总结了旨在理解血管平滑肌机械转导过程的近期研究工作。
