Singh I, Killen P D, Leichtman A B
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0364, USA.
J Am Soc Nephrol. 1995 Aug;6(2):165-70. doi: 10.1681/ASN.V62165.
Cholesterol emboli are a common complication of atherosclerotic vascular disease. A 40-yr-old renal transplant recipient who developed acute allograft dysfunction 1 day after the initiation of cyclosporine therapy and 6 days after transplantation is described. A renal allograft biopsy revealed cholesterol emboli in interlobular arteries and in glomeruli. Four previously reported cases of cholesterol emboli in renal allografts are described, and the cause and pathogenesis of atheroembolic disease are reviewed. Atheroemboli causing injury to the renal allograft may arise from either donor or recipient vessels. Vigilance for the occurrence of these emboli needs to be maintained when donor or recipient vessels demonstrate evidence of significant atherosclerotic vascular disease.
胆固醇栓子是动脉粥样硬化性血管疾病的常见并发症。本文描述了一名40岁的肾移植受者，在开始环孢素治疗1天后及移植6天后出现急性移植肾功能障碍。肾移植活检显示小叶间动脉和肾小球中有胆固醇栓子。文中还描述了4例先前报道的肾移植中胆固醇栓子的病例，并对动脉粥样硬化栓塞性疾病的病因和发病机制进行了综述。导致肾移植损伤的动脉粥样硬化栓子可能来自供体或受体血管。当供体或受体血管出现明显动脉粥样硬化性血管疾病的证据时，需要警惕这些栓子的发生。
