Anderson G, Jenkinson E J
Department of Anatomy, Medical School, University of Birmingham, Edgbaston, UK.
Semin Immunol. 1995 Jun;7(3):177-83. doi: 10.1016/1044-5323(95)90045-4.
To date, fetal thymic organ culture is the only in-vitro system capable of supporting a complete programme of T-lymphocyte development in a manner comparable to that seen in vivo. In this review, we will summarise recent studies in which thymic organ cultures have been used to investigate the regulatory mechanisms of particular stages of thymocyte development. In addition, the use of other culture systems of T-cell maturation will be discussed in an attempt to define the optimal conditions for T-cell development in vitro.
迄今为止，胎儿胸腺器官培养是唯一能够以与体内情况相当的方式支持完整T淋巴细胞发育程序的体外系统。在这篇综述中，我们将总结最近的研究，其中胸腺器官培养已被用于研究胸腺细胞发育特定阶段的调控机制。此外，还将讨论其他T细胞成熟培养系统的使用，以试图确定体外T细胞发育的最佳条件。
