Laitinen J, Liesivuori J, Savolainen H
Regional Institute of Occupational Health, Kuopio, Finland.
Occup Med (Lond). 1995 Oct;45(5):259-62. doi: 10.1093/occmed/45.5.259.
Ten car mechanics frequently exposed to glycol-based cooling liquids were followed during a workshift. Airborne ethylene and propylene glycol concentrations in the car mechanics' environment were measured. The car mechanics gave urine samples after the workshift and their excretion of ethylene glycol, propylene glycol, oxalic acid, calcium and ammonia was analysed and compared to that of unexposed office workers. Urinary succinate dehydrogenase activity and glycosaminoglycans were also measured in both groups. Airborne ethylene and propylene glycol concentrations in the car mechanics' environment were negligible. Urinary ethylene glycol excretion in exposed workers was significantly higher than that in unexposed workers, but propylene glycol excretion was at the same levels as in controls. In the exposed group, the excretion of the end metabolite of ethylene glycol, oxalic acid (47 +/- 11 mmol/mol creatinine, mean +/- SD, n = 10) differed slightly from that of controls (36 +/- 14 mmol/mol creatinine, mean +/- SD, n = 10). Urinary excretion of ammonia was higher among exposed workers than office workers. The excretion of calcium did not differ from that of controls. A marginally decreased urinary succinate dehydrogenase activity was found in the exposed men. The excretion of glycosaminoglycans was significantly lower in exposed workers. Therefore, it seems that ethylene glycol is absorbed by skin contact. The internal body burden is associated with oxaluria and increased ammoniagenesis typical of chronic acidosis.
在一个工作日期间，对10名经常接触乙二醇基冷却液的汽车修理工进行了跟踪研究。测量了汽车修理工工作环境中空气中乙烯和丙二醇的浓度。下班后，汽车修理工提供了尿液样本，并分析了他们乙二醇、丙二醇、草酸、钙和氨的排泄情况，并与未接触的办公室工作人员进行了比较。还测量了两组人员尿液中的琥珀酸脱氢酶活性和糖胺聚糖。汽车修理工工作环境中空气中乙烯和丙二醇的浓度可忽略不计。接触组工人尿液中乙二醇的排泄量显著高于未接触组工人，但丙二醇的排泄量与对照组相同。在接触组中，乙二醇最终代谢产物草酸的排泄量（47±11 mmol/mol肌酐，平均值±标准差，n = 10）与对照组（36±14 mmol/mol肌酐，平均值±标准差，n = 10）略有不同。接触组工人尿液中氨的排泄量高于办公室工作人员。钙的排泄量与对照组无差异。在接触组男性中发现尿液琥珀酸脱氢酶活性略有下降。接触组工人糖胺聚糖的排泄量显著较低。因此，似乎乙二醇是通过皮肤接触被吸收的。体内负担与草酸盐尿症和慢性酸中毒典型的氨生成增加有关。
