果蝇和脊椎动物发育中的刺猬基因家族。

The hedgehog gene family in Drosophila and vertebrate development.

作者信息

Fietz M J, Concordet J P, Barbosa R, Johnson R, Krauss S, McMahon A P, Tabin C, Ingham P W

机构信息

Molecular Embryology Laboratory, ICRF Developmental Biology Unit, Department of Zoology, Oxford, UK.

出版信息

Dev Suppl. 1994:43-51.

PMID:7579523

Abstract

The segment polarity gene hedgehog plays a central role in cell patterning during embryonic and post-embryonic development of the dipteran, Drosophila melanogaster. Recent studies have identified a family of hedgehog related genes in vertebrates; one of these, Sonic hedgehog is implicated in positional signalling processes that show interesting similarities with those controlled by its Drosophila homologue.

摘要

节段极性基因刺猬蛋白在双翅目昆虫黑腹果蝇的胚胎发育和胚后发育过程中的细胞模式形成中起着核心作用。最近的研究在脊椎动物中鉴定出了一个与刺猬蛋白相关的基因家族；其中之一，音猬因子，参与了位置信号传导过程，这些过程与由其果蝇同源物控制的过程表现出有趣的相似性。