隔室边界与刺猬蛋白对果蝇肢体模式的控制

Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein.

作者信息

Basler K, Struhl G

机构信息

Zoologisches Institut, Universität Zürich, Switzerland.

出版信息

Nature. 1994 Mar 17;368(6468):208-14. doi: 10.1038/368208a0.

DOI:10.1038/368208a0

PMID:8145818

Abstract

Drosophila limbs are subdivided into anterior and posterior compartments which derive from adjacent cell populations founded early in development. Evidence is now provided that posterior cells organize growth and cell patterning in both compartments by secreting hedgehog protein and that hedgehog protein acts indirectly by inducing neighbouring anterior cells to secrete decapentaplegic or wingless protein.

摘要

果蝇的肢体被分为前部和后部区域，这两个区域源自发育早期相邻的细胞群体。现在有证据表明，后部细胞通过分泌刺猬蛋白来组织两个区域的生长和细胞模式形成，并且刺猬蛋白通过诱导相邻的前部细胞分泌果蝇转化生长因子β或无翅蛋白而间接发挥作用。