1,25 - 二羟基维生素D3联合视黄酸或地塞米松对乳腺癌和卵巢癌细胞生长的抑制作用
Inhibition of breast and ovarian carcinoma cell growth by 1,25-dihydroxyvitamin D3 combined with retinoic acid or dexamethasone.
作者信息
Saunders D E, Christensen C, Williams J R, Wappler N L, Lawrence W D, Malone J M, Malviya V K, Deppe G
机构信息
CS Mott Center, Department of OB/GYN, Wayne State University, Detroit, MI 48201, USA.
出版信息
Anticancer Drugs. 1995 Aug;6(4):562-9. doi: 10.1097/00001813-199508000-00009.
This study examined the growth inhibitory effects of combining 1,25-dihydroxyvitamin D3 (calcitriol) with retinoic acid or dexamethasone against cultured breast and ovarian carcinoma cells. Retinoic acid (12.5-50 nM) increased the effectiveness of calcitriol (12.5-50 nM) against MCF-7 and NIH:OVCAR3 cells, with synergistic interactions at two of the three ratios tested. Dexamethasone augmented calcitriol effects, with synergism at 0.05 and 0.1 nM dexamethasone in MCF-7 cells and 5 nM in Caov-4 ovarian cells. This study showed favorable interactions for calcitriol-retinoic acid and calcitriol-dexamethasone combinations in breast and ovarian cancer cell lines.
本研究检测了1,25 - 二羟基维生素D3（骨化三醇）与视黄酸或地塞米松联合使用对培养的乳腺癌和卵巢癌细胞的生长抑制作用。视黄酸（12.5 - 50 nM）增强了骨化三醇（12.5 - 50 nM）对MCF - 7和NIH:OVCAR3细胞的作用，在测试的三个比例中的两个比例下存在协同相互作用。地塞米松增强了骨化三醇的作用，在MCF - 7细胞中，0.05和0.1 nM地塞米松以及在Caov - 4卵巢细胞中5 nM地塞米松时存在协同作用。本研究表明骨化三醇 - 视黄酸和骨化三醇 - 地塞米松组合在乳腺癌和卵巢癌细胞系中具有良好的相互作用。
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