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[抗NA 2同种免疫诱导的新生儿中性粒细胞减少症。一个家族中2例病例的血清学和临床研究]

[Neo-natal neutropenia induced by anti-NA 2 allo-immunization. Serological and clinical study of 2 cases in a family].

作者信息

Messer J, Tongio M M, Willard D, Mayer S, Daltroff G

出版信息

Arch Fr Pediatr. 1978 Oct;35(8):875-80.

PMID:757977
Abstract

A severe neutropenia in a 2 day old newborn drew attention to anti-HLA and NA 2 antigranulocytic antibodies in the maternal serum. Close supervision from birth of a younger sibling demonstrated a neutropenia on the 5th day of life. Serological investigation showed the anti-NA 2 antibody to be responsible in both cases. A good result with total blood replacement of leucocyte-free blood in the second case would advocate this treatment in cases of severe immunological neutropenia.

摘要

一名2日龄新生儿的严重中性粒细胞减少症引起了对母体血清中抗HLA和抗NA 2抗粒细胞抗体的关注。对一名较年幼同胞自出生起进行密切监测,发现其在出生后第5天出现中性粒细胞减少症。血清学调查显示,两例病例均由抗NA 2抗体所致。第二例病例中采用无白细胞全血置换取得了良好效果,这表明对于严重免疫性中性粒细胞减少症病例可采用这种治疗方法。

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