Boudghène F, Sapoval M, Bigot J M, Michel J B
Department of Radiology, Hopital Tenon, Paris, France.
J Vasc Interv Radiol. 1995 Jul-Aug;6(4):501-7. doi: 10.1016/s1051-0443(95)71123-x.
To test the effectiveness of endoluminal exclusion of the false lumen in experimental thoracic aortic dissection by occlusion of the entry site with a balloon-expandable endograft.
Thoracic aortic dissections were induced surgically in six beagles. The endograft consisted of an ultrathin, 12-mm-wide polyester tube sutured over a Strecker stent that was already crimped onto an angioplasty balloon. Fluoroscopic and intravascular ultrasonographic (IVUS) guidance were used. Endografts were introduced by means of femoral arteriotomy, via a 12-F sheath positioned in the aorta, and were then expanded on the angioplasty catheter.
IVUS and aortography showed an extensive thoracic dissection in all animals. Only four of six endografts were successfully placed. At 1 month, all thoracic endografts were patent, but the false lumen was never thrombosed. IVUS scans demonstrated a malpositioned endograft in two cases and persistent reentry in all cases.
Endovascular grafting of the aorta was feasible in experimental thoracic aortic dissection, but thrombosis of the false lumen was not achieved.
通过使用球囊扩张型腔内移植物封堵入口部位，测试腔内封堵实验性胸主动脉夹层假腔的有效性。
对6只比格犬进行外科手术诱导形成胸主动脉夹层。腔内移植物由一根超薄的、12毫米宽的聚酯管组成，该聚酯管缝合在已压接在血管成形术球囊上的施特雷克支架上。采用荧光透视和血管内超声（IVUS）引导。通过股动脉切开术，经置于主动脉内的12F鞘管引入腔内移植物，然后在血管成形术导管上进行扩张。
IVUS和主动脉造影显示所有动物均有广泛的胸主动脉夹层。6个腔内移植物中仅4个成功置入。1个月时，所有胸主动脉腔内移植物均通畅，但假腔从未形成血栓。IVUS扫描显示2例腔内移植物位置不当，所有病例均持续存在再入口。
在实验性胸主动脉夹层中，主动脉腔内植入移植物是可行的，但未实现假腔血栓形成。
