催化抗体：蛋白质功能的实时进化

Catalytic antibodies: evolution of protein function in real time.

作者信息

Lerner R A, Janda K D

机构信息

Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, USA.

出版信息

EXS. 1995;73:121-38. doi: 10.1007/978-3-0348-9061-8_7.

DOI:10.1007/978-3-0348-9061-8_7

PMID:7579971

Abstract

Natural selection of enzyme function has evolved over millions to billions of years, whereas antibody induction operates over a period of weeks. If one considers how new protein functions are generated, one sees that both the immune system and natural selection have powerful methods for the generation of diversity. In this treatise we discuss antibody catalysis from an evolutionary standpoint as we consider how the elicitation of a catalytic antibody can be a useful tool for exploring the nature of biological catalysis.

摘要

酶功能的自然选择历经数百万年至数十亿年的演化，而抗体诱导作用则在数周时间内发挥作用。如果思考一下新蛋白质功能是如何产生的，就会发现免疫系统和自然选择都拥有强大的多样性生成方法。在本论文中，我们从进化的角度探讨抗体催化作用，同时思考催化抗体的诱导如何能够成为探索生物催化本质的有用工具。