Jacobsen J R, Schultz P G
University of California at Berkeley, USA.
Curr Opin Struct Biol. 1995 Dec;5(6):818-24. doi: 10.1016/0959-440x(95)80016-6.
New strategies for hapten design have led to antibodies that catalyze reactions by increasingly complex mechanisms and with large increases in catalytic rate. Rational design has also been used to elicit catalytic antibodies for difficult chemical transformations as well as reactions for which no enzyme is known. These experiments have demonstrated the chemical potential of large combinatorial libraries that have been given appropriate mechanistic instruction.
半抗原设计的新策略已产生了一些抗体，这些抗体通过日益复杂的机制催化反应，且催化速率大幅提高。合理设计也已用于引发针对困难化学转化以及尚无已知酶催化反应的催化抗体。这些实验证明了经过适当机制指导的大型组合文库的化学潜力。
