Behr B, Stone B, Foote W D
Department of Biology, University of Nevada-Reno 89504, USA.
J Assist Reprod Genet. 1995 Apr;12(4):278-82. doi: 10.1007/BF02212932.
While the precise timing of the maternal recognition of pregnancy is not known, it is known that the prevention of return to ovarian cyclicity relies on a conceptus-derived signal.
In an attempt to identify the first luteotropic signals detectable in the maternal circulation, a sensitive Leydig cell luteotropin bioassay was employed, and data were compared for nine clinically pregnant and nine nonpregnant patients in an in vitro fertilization program. Blood samples were drawn every other day for 10 days after embryo transfer (ET).
The first detectable rise in bioactive luteotropin levels occurred between 6 and 8 days post ET. Serum E2 levels increased on the same days. Differences in luteotropin levels between pregnant and nonpregnant patients were significant between days 6 and 8 (P < 0.0001) and between days 8 and 10 (P < 0.002).
Based on morphological studies reported by others, bioactive luteotropic signals identified in this study were detectable in the maternal circulation at about the time of trophoblast lacunae coalescing with maternal uterine blood vessels.
虽然母体识别妊娠的确切时间尚不清楚，但已知防止卵巢周期性恢复依赖于来自孕体的信号。
为了识别母体循环中可检测到的首个促黄体信号，采用了灵敏的莱迪希细胞促黄体素生物测定法，并对体外受精项目中的9名临床妊娠患者和9名未妊娠患者的数据进行了比较。胚胎移植（ET）后每隔一天采集血样，共采集10天。
生物活性促黄体素水平首次可检测到的升高发生在胚胎移植后6至8天。血清雌二醇（E2）水平在同一天升高。妊娠患者和未妊娠患者的促黄体素水平在第6至8天（P < 0.0001）和第8至10天（P < 0.002）存在显著差异。
根据其他人报告的形态学研究，本研究中鉴定出的生物活性促黄体信号在滋养层腔隙与母体子宫血管融合时可在母体循环中检测到。
