Liu Y C, Liu G Y, Liu R L
Weifang Medical College, Shandong.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995 Jul;15(7):422-3.
In order to prevent the ototoxicity of kanamycin (KM), the effects of Poria Cocos (PC) on the ototoxicity induced by KM in guinea-pigs was observed by infusing the PC decoction into the guinea-pigs with comparing the difference in the general intoxicating symptom, prayer's reflex (PR) threshold, brainstem auditory evoked potentials (BAEPs) and the absence rate of outer hair cells in the first turn of cochlea. The results suggested that the ototoxicity of KM was retarded by giving the PC decoction. On 7th day after given KM, PR threshold of 4,6,8 kHz in the medicated group and control group were 4.7 +/- 1.5 dB, 5.7 +/- 2.4 dB, 2.7 +/- 1.2 dB and 10.5 +/- 3.2 dB, 12.1 +/- 3.7 dB, 8.5 +/- 2.7 dB respectively. BAEPs threshold on 13th day given KM raised 22.7 +/- 9.7 dB in the medicated group and 51.3 +/- 14.4 dB in control group. The absence rate of outer hair cells in first turn of cochlea were 39.4% and 67.4% respectively. The results suggested that PC might be antagonistic to the ototoxicity of KM in guinea-pigs.
为预防卡那霉素（KM）的耳毒性，通过给豚鼠灌服茯苓（PC）水煎剂，观察其对KM所致豚鼠耳毒性的影响，并比较一般中毒症状、听觉脑干反应（PR）阈值、脑干听觉诱发电位（BAEPs）以及耳蜗第一圈外毛细胞缺失率的差异。结果表明，灌服PC水煎剂可延缓KM的耳毒性。给予KM后第7天，用药组和对照组4、6、8kHz的PR阈值分别为4.7±1.5dB、5.7±2.4dB、2.7±1.2dB和10.5±3.2dB、12.1±3.7dB、8.5±2.7dB。给予KM后第13天，用药组BAEPs阈值升高22.7±9.7dB，对照组升高51.3±14.4dB。耳蜗第一圈外毛细胞缺失率分别为39.4%和67.4%。结果提示，PC可能对豚鼠KM耳毒性具有拮抗作用。
