Kuhse J, Betz H, Kirsch J
Department of Neurochemistry, Max-Planck-Institute for Brain Research, Frankfurt, Germany.
Curr Opin Neurobiol. 1995 Jun;5(3):318-23. doi: 10.1016/0959-4388(95)80044-1.
Significant progress has been made towards the identification of functional domains of the inhibitory glycine receptor. Several residues crucial for ligand binding, ion-channel properties and stoichiometric subunit assembly have been identified. A major recent advance has been the finding that the biogenesis of postsynaptic glycine receptor clusters requires the tubulin-binding protein, gephyrin. Another area of exciting research has focused on mutations of glycine receptor alpha and beta subunit genes, which have been found to be causal for different hereditary motor disorders.
在抑制性甘氨酸受体功能域的识别方面已取得重大进展。已确定了几个对配体结合、离子通道特性和化学计量亚基组装至关重要的残基。最近的一项重大进展是发现突触后甘氨酸受体簇的生物发生需要微管蛋白结合蛋白gephyrin。另一个令人兴奋的研究领域集中在甘氨酸受体α和β亚基基因的突变上，这些突变已被发现是不同遗传性运动障碍的病因。
