Breitinger H G, Becker C M
Institut für Biochemie, Universität Erlangen-Nürnberg, Germany.
Curr Pharm Des. 1998 Aug;4(4):315-34.
The inhibitory glycine receptor is a member of the ligand-gated ion channel superfamily. It mediates inhibitory synaptic transmission in mammalian spinal cord and brainstem. Structure and function of the receptor, as well as its chromosomal localization and genetic structure, have been extensively studied. While hereditary and acquired receptor dysfunctions can be identified, selective and specific modulation of receptor function is still lacking. The preponderance of current literature regarding the inhibitory glycine receptor raises the prospect that adequate methods for the treatment of glycine receptor-mediated disorders might be developed.
抑制性甘氨酸受体是配体门控离子通道超家族的成员。它介导哺乳动物脊髓和脑干中的抑制性突触传递。该受体的结构与功能，以及其染色体定位和基因结构均已得到广泛研究。虽然可以识别遗传性和获得性受体功能障碍，但仍缺乏对受体功能的选择性和特异性调节。当前关于抑制性甘氨酸受体的大量文献表明，或许能够开发出治疗甘氨酸受体介导疾病的适当方法。
