Figiel G S, Krishnan K R, Rao V P, Doraiswamy M, Ellinwood E H, Nemeroff C B, Evans D, Boyko O
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
J Neuropsychiatry Clin Neurosci. 1991 Winter;3(1):18-22. doi: 10.1176/jnp.3.1.18.
Bipolar disorder has been reported to occur frequently in a number of subcortical diseases. This suggests that subcortical structures may be involved in the etiology of bipolar disorder in some patients. With the advent of brain magnetic resonance imaging (MRI), in vivo visualization of the subcortical white and gray matter is now possible, allowing the examination of these structures. The authors report a higher occurrence of deep white matter lesions in bipolar patients (44%) compared with age-matched controls (6%). The neuroanatomic and clinical correlates of these lesions will be discussed, along with their potential pathophysiologic significance.
据报道，双相情感障碍在许多皮质下疾病中经常出现。这表明在一些双相情感障碍患者中，皮质下结构可能参与了其病因学。随着脑磁共振成像（MRI）的出现，现在可以在活体中可视化皮质下白质和灰质，从而能够对这些结构进行检查。作者报告称，与年龄匹配的对照组（6%）相比，双相情感障碍患者中深部白质病变的发生率更高（44%）。将讨论这些病变的神经解剖学和临床相关性，以及它们潜在的病理生理学意义。
