Lott A D, McElroy S L, Keys M A
Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267, USA.
J Neuropsychiatry Clin Neurosci. 1995 Summer;7(3):314-9. doi: 10.1176/jnp.7.3.314.
Ten nursing home patients ages 71 to 94 years with dementia and behavioral agitation were treated prospectively with open-label valproate at doses of 375 to 750 mg/day over periods of time ranging from 4 to 34 weeks. Change in behavioral agitation was rated by nursing staff members. Eight (80%) of the 10 patients showed a 50% or greater reduction in the frequency of episodes of behavioral agitation. Response was maintained in all patients. Side effects were minimal. The authors conclude that valproate may be an effective, well tolerated, and safe treatment for behavioral agitation in elderly patients with dementia.
对10名年龄在71至94岁之间患有痴呆症且有行为激越症状的疗养院患者进行了前瞻性治疗，给予开放标签的丙戊酸盐，剂量为375至750毫克/天，治疗时间为4至34周。护理人员对行为激越的变化进行评分。10名患者中有8名（80%）行为激越发作频率降低了50%或更多。所有患者的疗效均得以维持。副作用极小。作者得出结论，丙戊酸盐可能是治疗老年痴呆症患者行为激越的一种有效、耐受性良好且安全的疗法。
