Mortel K F, Meyer J S
Cerebral Blood Flow Laboratory, Department of Veterand Affairs Medical Center, Houston, TX 77030, USA.
J Neuropsychiatry Clin Neurosci. 1995 Summer;7(3):334-7. doi: 10.1176/jnp.7.3.334.
Estrogen replacement therapy (ERT) and associated risks for ischemic vascular dementia (IVD) and dementia of the Alzheimer's type (DAT) among postmenopausal women were investigated by determining whether ERT was differently distributed among control subjects than among subjects with dementia. Subjects included 93 with probable DAT, 65 with probable IVD, and 148 normal control subjects. The proportion of control subjects on ERT was almost 2:1, and this ratio holds for both dementia groups. Logistic regression suggests lack of ERT is associated with increased risk for dementia among elderly women. ERT may eventually prove to be a useful prophylactic agent for reducing risk of DAT and IVD among postmenopausal women.
通过确定雌激素替代疗法（ERT）在对照组和痴呆症患者中的分布是否存在差异，研究了绝经后女性中ERT与缺血性血管性痴呆（IVD）和阿尔茨海默病型痴呆（DAT）的相关风险。研究对象包括93例可能患有DAT的患者、65例可能患有IVD的患者以及148例正常对照者。接受ERT治疗的对照者比例几乎为2:1，两个痴呆症组的这一比例也是如此。逻辑回归分析表明，未接受ERT治疗与老年女性患痴呆症的风险增加有关。ERT最终可能被证明是一种有用的预防药物，可降低绝经后女性患DAT和IVD的风险。
