Bogden A E, Esber H J
Natl Cancer Inst Monogr. 1978 Dec(49):263-7.
As an introduction to the session on Animal Tumor Models, a concept of animal model systems in presented that differentiates between models of organ-related diseases such as prostate or bladder cancer and models of a certain class of neoplasms found within a specific organ disease. Thus defined, no one animal tumor can completely represent and be predictive for a disease entity, no more so than can a single clinical experience with prostate cancer, e.g., be representative of all clinical cases. Rather, a block of animal tumors originating from a specific organ that reflects a spectrum of carefully defined growth patterns and reactivities best mimics the overall responses obtained clinically. Because immunotherapy is most logically visualized and applied in an adjuvant mode, its effectiveness as a therapeutic modality is vulnerable to the vagaries of individual tumor response to a primary modality. Therefore, the selection of appropriate tumor models for developmental studies in immunotherapy is critical, and the need for well-defined and characterized test systems in terms of chemotherapy and radiation responsiveness is emphasized.
作为动物肿瘤模型专题讨论会的引言，文中介绍了动物模型系统的概念，该概念区分了器官相关疾病（如前列腺癌或膀胱癌）的模型以及特定器官疾病中发现的某类肿瘤的模型。如此定义后，没有一种动物肿瘤能够完全代表一种疾病实体并对其具有预测性，就如同前列腺癌的单一临床经验无法代表所有临床病例一样。相反，源自特定器官的一组动物肿瘤，反映了一系列精心定义的生长模式和反应性，最能模拟临床上获得的总体反应。由于免疫疗法在逻辑上最适合以辅助模式进行设想和应用，其作为一种治疗方式的有效性容易受到个体肿瘤对主要治疗方式反应的变幻莫测的影响。因此，选择合适的肿瘤模型用于免疫疗法的开发研究至关重要，并且强调了在化疗和放疗反应性方面需要明确界定和特征化的测试系统。
