Ruedl C, Wolf H
Institute for General and Experimental Pathology, Medical School, University of Innsbruck, Austria.
Int Arch Allergy Immunol. 1995 Dec;108(4):334-9. doi: 10.1159/000237177.
In this review, we focus on some key areas concerning the unique properties of the mucosal immune system. They are: (1) the fact that the common mucosal immune system consists of different compartments; (2) the advantages of oral vaccination, which can be exploited to antigen-specific sIgA-mediated local immune responses as well as systemic immunity; (3) efficacious oral immunization against respiratory infections; (4) oral tolerance with respect to activation of T cells which, after declining, can be repeatedly reinduced without changes in profile or magnitude, and (5) the use of transgenic plants as a new vaccine source for a new vaccination strategy, i.e. employing edible dietary vaccines.
在本综述中，我们聚焦于黏膜免疫系统独特性质的一些关键领域。它们是：（1）共同黏膜免疫系统由不同部分组成这一事实；（2）口服疫苗接种的优势，可利用其引发抗原特异性分泌型免疫球蛋白A（sIgA）介导的局部免疫反应以及全身免疫；（3）针对呼吸道感染的有效口服免疫；（4）关于T细胞激活的口服耐受，T细胞激活后功能下降，但可反复重新诱导，且其特征或强度无变化；以及（5）将转基因植物用作新疫苗来源以采用新的疫苗接种策略，即使用可食用的饮食疫苗。
