Serum concentrations of orally administered diphenylhydantoin in dogs.
作者信息
Sanders J E, Yeary R A
出版信息
J Am Vet Med Assoc. 1978 Jan 15;172(2):153-6.
PMID:758073
Abstract
Diphenylhydantoin was found to have a short half life and poor gastrointestinal absorption in dogs. Consequently, serum content after single or repeated oral dosage of 10 mg/kg of body weight did not exceed a concentration of 2 microgram/ml. To achieve a postulated effective plasma concentration of diphenylhydantoin, oral dosage of at least 35 mg/kg of body weight 3 times daily seems necessary.
摘要
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