Araujo N P, Monteiro M G
Department of Psychobiology, Escola Paulista de Medicina, São Paulo, Brazil.
Addiction. 1995 Sep;90(9):1205-11. doi: 10.1046/j.1360-0443.1995.90912055.x.
The present study was aimed at replicating, in a sample of Brazilian subjects, findings generated mostly in developed countries on the relative prevalence of alcohol problems, associated psychiatric disorders, family history of alcoholism and other familial psychiatric disorders in alcoholics and controls. A group of Brazilian male alcoholics (n = 103) and controls (n = 63) at first admission to ambulatory or inpatient treatment were interviewed individually using sections of the Structured Clinical Interview for DSM-III-R. Information on demographic characteristics, alcohol-related problems, psychiatric problems and family history of alcoholism and depression were collected from all subjects. Alcoholics had a higher prevalence of a family history of alcoholism, a family history of depression and of a personal history of other psychiatric disorders when compared to controls. Comparisons between FHP and FHN alcoholics, although preliminary, showed few significant differences between these subgroups. Comparisons between FHP and FHN control showed a non-significant trend towards a higher prevalence of psychiatric problems and towards antisocial behaviours among those with a positive family history of alcoholism. The findings point to the importance of cross-cultural studies on genetic and environmental factors related to alcohol dependence.
本研究旨在以巴西人为样本，复制多数在发达国家得出的关于酒精问题的相对患病率、相关精神障碍、酗酒家族史以及酗酒者和对照组中其他家族性精神障碍的研究结果。一组首次接受门诊或住院治疗的巴西男性酗酒者（n = 103）和对照组（n = 63）使用《DSM-III-R结构化临床访谈》的部分内容进行了单独访谈。从所有受试者收集了有关人口统计学特征、与酒精相关的问题、精神问题以及酗酒和抑郁症家族史的信息。与对照组相比，酗酒者的酗酒家族史、抑郁症家族史以及其他精神障碍个人史的患病率更高。尽管是初步的，但FHP和FHN酗酒者之间的比较显示这些亚组之间几乎没有显著差异。FHP和FHN对照组之间的比较显示，酗酒家族史呈阳性者的精神问题患病率和反社会行为患病率有不显著的上升趋势。研究结果表明跨文化研究对于与酒精依赖相关的遗传和环境因素的重要性。
