Bidaut-Russell M, Bradford S E, Smith E M
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
Drug Alcohol Depend. 1994 Apr;35(2):81-90. doi: 10.1016/0376-8716(94)90114-7.
Recognition of maternal alcoholism as a risk factor for mental illness in adult offspring is important. Using the Diagnostic Interview Schedule (DIS), adult offspring of a clinical sample of alcoholic mothers were assessed for selected lifetime psychiatric disorders. Elevated adjusted odds ratio (OR) of alcohol abuse/dependence (OR 6.18, 95% confidence interval (CI) 2.0-19.02), and drug abuse/dependence (OR 3.75, 95% CI 1.13-12.34) were observed for daughters of alcoholic mothers compared with a group of women who reported no history of alcoholism in their parents. Prevalence rates of alcohol abuse/dependence, drug abuse/dependence, affective disorders, general anxiety disorder, panic disorder and schizophrenia were higher in sons of alcoholic mothers than in a male comparison sample who reported no history of parental alcoholism, however, these increases were not statistically significant.
认识到母亲酗酒是成年子女患精神疾病的一个风险因素很重要。使用诊断访谈表（DIS），对临床样本中酗酒母亲的成年子女进行选定的终生精神疾病评估。与一组报告父母无酗酒史的女性相比，酗酒母亲的女儿中酒精滥用/依赖的调整优势比（OR）升高（OR 6.18，95%置信区间（CI）2.0 - 19.02），药物滥用/依赖的调整优势比（OR 3.75，95%CI 1.13 - 12.34）。酗酒母亲的儿子中酒精滥用/依赖、药物滥用/依赖、情感障碍、广泛性焦虑症、恐慌症和精神分裂症的患病率高于报告父母无酗酒史的男性对照样本，然而，这些增加在统计学上并不显著。
