Rosati G, Pinna L, Granieri E, Aiello I, De Bastiani P, Tola R, Agnetti V, Pirisi A
Riv Patol Nerv Ment. 1977 Jan-Feb;98(1):46-64.
The incidence of M.S. in Sardinia has been found to be the highest in Southern Italy. On "prevalence day", October 21st, 1971, the incidence was 12.48/100,000 inhabitants, whereas the rates in Campania and in Puglia, (regions of Southern Italy at the same latitude as Sardinia) the rates were 3.3 and 4.0 respectively. In the present study, a significant female predominance was found, the rates for women and men being 15.88 and 9.03 respectively. The incidence of MS in the study area was found to be significantly higher both in areas with a cool humid climate and in communities with the lowest socioeconomic conditions. A significantly higher incidence was computed for communities with less than 5,000 inhabitants. MS incidence had no correlation with the occupational status and dietary habits, which are uniformly distributed throughout the island. The disease started at au average of 27.3 years and its duration on "prevalence day" was 13.4 years. The age of onset was found to be low in comparison with other population studies in Europe and in North-Central Italy. The age-specific curves of onset and on "prevalence day" showed two peaks, one in the second-third decade and one in the forth-fifth decade. Most of the patients with an earlier onset showed a complete disappearance of the symptoms after the first bout.
撒丁岛多发性硬化症的发病率在意大利南部地区是最高的。在1971年10月21日的“患病率日”，发病率为每10万居民中有12.48例，而坎帕尼亚和普利亚（与撒丁岛处于同一纬度的意大利南部地区）的发病率分别为3.3例和4.0例。在本研究中，发现女性占显著优势，女性和男性的发病率分别为15.88和9.03。研究区域内，在气候凉爽潮湿的地区以及社会经济条件最低的社区，多发性硬化症的发病率明显更高。计算得出居民少于5000人的社区发病率显著更高。多发性硬化症的发病率与职业状况和饮食习惯无关，这些在全岛分布均匀。该病平均发病年龄为27.3岁，在“患病率日”的病程为13.4年。与欧洲和意大利中北部的其他人群研究相比，发病年龄较低。发病时和“患病率日”的年龄别曲线显示有两个高峰，一个在二三十岁，另一个在四五十岁。大多数发病较早的患者在首次发作后症状完全消失。
