Debouverie M, Pittion-Vouyovitch S, Louis S, Roederer T, Guillemin F
Department of Neurology, Central Hospital, 54000 Nancy, France, EA 4003, Nancy-Université, School of Public Health, Faculté de Médecine, Avenue de la Forêt de Haye, 54500 Vandoeuvre-lès-Nancy, France.
Mult Scler. 2007 Sep;13(8):962-7. doi: 10.1177/1352458507077938. Epub 2007 Jul 10.
This study aims to describe the prevalence and incidence rates of multiple sclerosis (MS) in Lorraine, France, and its secular trend from 1990 to 2002. Cases were sourced from the regional network of MS healthcare workers in the Lorraine region and include all cases with definite or probable MS according to Poser's criteria. We identified 2718 patients with MS on 31 December 2004. The prevalence rate was 120/100,000 (95% confidence interval [CI]: 119-121). Between 1990 and 2002, the average age- and sex-adjusted annual incidence rate was 5.5/100,000 (95% CI: 4.4-6.6). During this same period, there was a significant increase in overall incidence in women but not in men. The mean age at MS onset, disability score five years after onset, number of relapses during the first five years, and proportion of first attack with sequelae or polysymptomatic symptoms were not significantly different between each annual cohort during the study period. The prevalence and incidence rates of MS we found in our study were higher than in previous studies in France. The increase in incidence of MS between 1990 and 2002, mostly in women, was not related to better ascertainment of patients with mild disability.
本研究旨在描述法国洛林地区多发性硬化症（MS）的患病率和发病率，以及1990年至2002年期间的长期趋势。病例来源于洛林地区MS医护人员的区域网络，包括所有根据波泽标准确诊或可能患有MS的病例。我们在2004年12月31日确定了2718例MS患者。患病率为120/10万（95%置信区间[CI]：119 - 121）。1990年至2002年期间，年龄和性别调整后的年平均发病率为5.5/10万（95%CI：4.4 - 6.6）。在同一时期，女性的总体发病率显著上升，而男性则没有。在研究期间，每年队列中MS发病的平均年龄、发病五年后的残疾评分、前五年的复发次数以及首次发作伴有后遗症或多症状的比例没有显著差异。我们研究中发现的MS患病率和发病率高于法国以前的研究。1990年至2002年期间MS发病率的上升，主要是在女性中，与对轻度残疾患者的更好确诊无关。
