Tsutsumi N
Central Research Laboratories, Kissei Pharmaceutical Co., Ltd., Nagano, Japan.
Biol Pharm Bull. 1995 Jul;18(7):1012-5. doi: 10.1248/bpb.18.1012.
Coumestrol, a representative phytoestrogen, inhibited bone resorption-stimulating agent-induced bone resorption, whereas it did not inhibit basal bone resorption of cultured fetal rat limb bone. Coumestrol increased the calcium content of 9-d-old chick embryonic femurs in organ culture, indicating that this phytoestrogen stimulated bone-mineralizing activity. Therefore, coumestrol is a unique substance in that it inhibits bone resorption and, at the same time, stimulates bone mineralization. Coumestrol exhibited less estrogenic activity than 17 beta-estradiol as estimated by the increase in uterine weight of ovariectomized rats. As coumestrol has less estrogenic activity than 17 beta-estradiol, it may prove to be a more potent drug against bone diseases including osteoporosis.
香豆雌酚是一种典型的植物雌激素，它能抑制骨吸收刺激剂诱导的骨吸收，但不抑制培养的胎鼠肢骨的基础骨吸收。在器官培养中，香豆雌酚增加了9日龄鸡胚股骨的钙含量，表明这种植物雌激素刺激了骨矿化活性。因此，香豆雌酚是一种独特的物质，它既能抑制骨吸收，同时又能刺激骨矿化。通过去卵巢大鼠子宫重量增加来估计，香豆雌酚的雌激素活性低于17β-雌二醇。由于香豆雌酚的雌激素活性低于17β-雌二醇，它可能被证明是一种治疗包括骨质疏松症在内的骨疾病的更有效药物。
