Inouye Y, Fujimoto Y, Sugiyama M, Yoshida T, Yamase T
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan.
Biol Pharm Bull. 1995 Jul;18(7):996-1000. doi: 10.1248/bpb.18.996.
The anti-human immunodeficiency virus (HIV) activity of polyoxometalates of representative structural families, such as Keggin, lacunary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich, was determined using two strains of HIV type 1 (HIV-1HTLV-IIIB and HIV-1SF-2H). The compounds were preferably selected to cover both polyoxotungstates and polyoxomolybdates in each structural family. In general, polyoxotungstates of Keggin, lacunary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich structures showed anti-HIV-1HTLVIIIB activity, whereas most compounds not included in these structural categories were inactive. Among the compounds with a potent anti-HIV-1HTLV-IIIB activity, those of Keggin and its closely related structural families (lacunary Keggin, trivacant Keggin and Keggin sandwich) inhibited the cytopathogenicity and syncytium formation caused by HIV-1SF-2 to a much higher extent compared with HIV-1HTLV-IIIB-related ones. The difference between the spectra of anti-HIV-1HTLV-IIIB activity and the specificity for HIV-1SF-2H might result from differential structural requirements in these functions.
利用两株1型人类免疫缺陷病毒（HIV-1HTLV-IIIB和HIV-1SF-2H）测定了具有代表性结构家族的多金属氧酸盐的抗HIV活性，这些结构家族包括Keggin、缺位Keggin、三缺位Keggin、Keggin夹心型、Wells-Dawson和Wells-Dawson夹心型。在每个结构家族中，优先选择既包含多钨酸盐又包含多钼酸盐的化合物。一般来说，具有Keggin、缺位Keggin、三缺位Keggin、Keggin夹心型、Wells-Dawson和Wells-Dawson夹心型结构的多钨酸盐表现出抗HIV-1HTLVIIIB活性，而这些结构类别之外的大多数化合物没有活性。在具有强效抗HIV-1HTLV-IIIB活性的化合物中，与HIV-1HTLV-IIIB相关的化合物相比，Keggin及其密切相关的结构家族（缺位Keggin、三缺位Keggin和Keggin夹心型）的化合物对HIV-1SF-2引起的细胞病变效应和合胞体形成的抑制作用要强得多。抗HIV-1HTLV-IIIB活性谱与对HIV-1SF-2H的特异性之间的差异可能源于这些功能中不同的结构要求。
