Wu X, Ackermann U, Sonnenberg H
Department of Physiology, University of Toronto, Ontario, Canada.
Clin Exp Hypertens. 1995 Aug;17(6):989-1008. doi: 10.3109/10641969509033647.
Weanling male inbred Dahl rats (Jr salt-sensitive (S) and salt-resistant (R) strains) were placed on high (4%, HK) and low (0.2%, LK) potassium diets for 4 weeks. Both diets contained 8% sodium chloride, 2.5% calcium, 0.8% magnesium, and 2.0% phosphorous. Balance studies were carried out during the final week on the diets. Mean arterial blood pressure was determined, and dietary intake and urinary output of water, sodium, chloride, potassium, calcium, magnesium, and phosphate were monitored daily during this period. The data show that blood pressures of S rats were significantly higher than those of R rats on both HK and LK diets; however, reduced dietary potassium was associated with increased blood pressure in both strains. Urinary excretions of calcium and magnesium were higher, and urinary phosphate excretion was lower, in S compared to R rats. Decreased potassium intake was associated with increased excretion of calcium, magnesium and phosphate in both strains. The changes in calcium and magnesium excretion were significantly correlated to blood pressure across strains and diets. We conclude that the effects of a high salt diet on increasing blood pressure can be potentiated by lack of potassium, even in previously salt-resistant rats. Increased blood pressure is associated with increased divalent cation excretion. It is not yet known whether this is a cause-and-effect relationship.
将断奶的雄性近交系达尔大鼠（Jr盐敏感（S）和盐抵抗（R）品系）分别置于高钾（4%，HK）和低钾（0.2%，LK）饮食中4周。两种饮食均含有8%的氯化钠、2.5%的钙、0.8%的镁和2.0%的磷。在饮食的最后一周进行平衡研究。测定平均动脉血压，并在此期间每天监测水、钠、氯、钾、钙、镁和磷酸盐的饮食摄入量和尿量。数据显示，在HK和LK饮食中，S大鼠的血压均显著高于R大鼠；然而，饮食中钾的减少与两种品系的血压升高有关。与R大鼠相比，S大鼠的尿钙和尿镁排泄量更高，而尿磷排泄量更低。钾摄入量的减少与两种品系钙、镁和磷酸盐排泄量的增加有关。跨品系和饮食的钙和镁排泄变化与血压显著相关。我们得出结论，即使在先前耐盐的大鼠中，低钾也可增强高盐饮食对血压升高的影响。血压升高与二价阳离子排泄增加有关。目前尚不清楚这是否存在因果关系。
