Davis G W
Neuroscience and Behavior Program, Morrill Science Center (South), University of Massachusetts, Amherst 01003, USA.
J Physiol Paris. 1995;89(1):33-41. doi: 10.1016/0928-4257(96)80549-3.
The dynamics of presynaptic transmitter release are often matched to the physiological properties and function of the postsynaptic cell. Evidence in organisms as diverse as the cricket central nervous system and the cat spinal cord suggests that retrograde signaling is essential for matching presynaptic release properties to the postsynaptic cell. The cricket central nervous system is favorably organized for analysis of synaptic function in the central nervous system. Several lines of independent evidence suggest that it is possible to reliably estimate the size of single quantal release events at the sensory to interneuron synapses of the cricket. A quantal analysis suggests that a retrograde influence on the probability of presynaptic release is responsible for matching presynaptic dynamic properties to postsynaptic targets. This retrograde interaction is hypothesized to be a long-term modification on the basal probability of presynaptic release.
突触前递质释放的动力学通常与突触后细胞的生理特性和功能相匹配。从蟋蟀中枢神经系统到猫脊髓等多种生物体中的证据表明，逆行信号传导对于使突触前释放特性与突触后细胞相匹配至关重要。蟋蟀中枢神经系统的组织结构有利于对中枢神经系统中的突触功能进行分析。多条独立证据表明，有可能可靠地估计蟋蟀感觉神经元与中间神经元突触处单个量子释放事件的大小。量子分析表明，对突触前释放概率的逆行影响负责使突触前动态特性与突触后靶点相匹配。这种逆行相互作用被认为是对突触前释放基础概率的长期修饰。
