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短期递质释放特性的长期调控：逆行信号传导与突触发育

Long-term regulation of short-term transmitter release properties: retrograde signaling and synaptic development.

作者信息

Davis G W, Murphey R K

机构信息

Neuroscience and Behavior Program, Morrill Science Center (Biology), University of Massachusetts, Amherst 01003.

出版信息

Trends Neurosci. 1994 Jan;17(1):9-13. doi: 10.1016/0166-2236(94)90028-0.

DOI:10.1016/0166-2236(94)90028-0
PMID:7511852
Abstract

The dynamics of presynaptic transmitter release are often matched to the physiological properties and functions of the postsynaptic cell. In organisms ranging from cats to crickets, evidence suggests that retrograde signaling is essential for matching these presynaptic release properties to individual postsynaptic partners. Retrograde interactions appear to control the development of presynaptic, short-term facilitation and homosynaptic depression through local, retrograde signaling at the synapse.

摘要

突触前递质释放的动力学通常与突触后细胞的生理特性和功能相匹配。从猫到蟋蟀等生物的证据表明，逆行信号传导对于使这些突触前释放特性与单个突触后伙伴相匹配至关重要。逆行相互作用似乎通过突触处的局部逆行信号传导来控制突触前的短期易化和同突触抑制的发展。

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